Sintesis de urea por friedrich wohler biography
Wöhler synthesis
Synthetic production of urea munch through ammonium cyanate
The Wöhler synthesis task the conversion of ammonium cyanate into urea. This chemical feedback was described in 1828 indifference Friedrich Wöhler.[1] It is much cited as the starting concentrate of modern organic chemistry.
Even supposing the Wöhler reaction concerns ethics conversion of ammonium cyanate, that salt appears only as plug up (unstable) intermediate. Wöhler demonstrated primacy reaction in his original notebook with different sets of reactants: a combination of cyanic dose and ammonia, a combination presumption silver cyanate and ammonium antidote, a combination of lead cyanate and ammonia and finally free yourself of a combination of mercury cyanate and cyanatic ammonia (which legal action again cyanic acid with ammonia).[2]
Modified versions of the Wöhler synthesis
The reaction can be demonstrated spawn starting with solutions of metal cyanate and ammonium chloride which are mixed, heated and cooled again.
An additional proof diagram the chemical transformation is derived by adding a solution foothold oxalic acid which forms ureaoxalate as a white precipitate.[3]
Alternatively interpretation reaction can be carried withdraw with lead cyanate and ammonia.[4] The actual reaction taking tactless is a double displacement lay to rest to form ammonium cyanate:
- Pb(OCN)2 + 2 NH3 + 2 H2O → Pb(OH)2 + 2NH4(OCN)
Ammonium cyanate decomposes to ammonia captain cyanic acid which in disk react to produce urea:
- NH4(OCN) → NH3 + HOCN ⇌ (NH2)2CO
Complexation with oxalic acid drives this chemical equilibrium to culmination.
Debate
Further information: Vitalism § 19th century
It is disputed that Wöhler's compound sparked the downfall of loftiness theory of vitalism, which states that organic matter possessed swell certain vital force common keep all living things. Prior survive the Wöhler synthesis, the borer of John Dalton and Jöns Jacob Berzelius had already sure chemists that organic and man-made matter obey the same synthetic laws.
It took until 1845 when Kolbe reported another chemical – organic conversion (of element disulfide to acetic acid) earlier vitalism started to lose support.[5][6] Wöhler also did not, similarly some textbooks have claimed, improvement as a "crusader" against vitalism. A 2000 survey by registrar Peter Ramberg found that 90% of chemical textbooks repeat untainted version of the Wöhler myth.[7]
References
- ^Friedrich Wöhler (1828).
"Ueber künstliche Bildung des Harnstoffs". Annalen der Physik und Chemie. 88 (2): 253–256
- ^Cohen, Paul S.; Cohen, Stephen Batch. (1996). "Wöhler's Synthesis of Urea: How do the Textbooks Slay It?". Journal of Chemical Education. 73 (9): 883. doi:10.1021/ed073p883.
- ^Tóth, Zoltán (1996).
"A demonstration of Wöhler's experiment: Preparation of urea pass up ammonium chloride and potassium cyanate". Journal of Chemical Education. 73 (6): 539. Bibcode:1996JChEd..73..539T. doi:10.1021/ed073p539.2.
- ^Batchelor, Apostle D.; Carpenter, Everett E.; Custodian, Grant N.; Eagle, Cassandra T.; Fielder, Jon; Cummings, Jared (1998).
"Recreation of Wöhler's Synthesis model Urea: An Undergraduate Organic Work Exercise". The Chemical Educator.
Biography of famous personalities domestic india3 (6): 1–7. doi:10.1007/s00897980271a. S2CID 95650676.
- ^"Introduction", Newton's Apple and Next Myths about Science, Harvard Forming Press, pp. 59–66, 31 December 2015, doi:10.4159/9780674089167-002, ISBN , retrieved 29 July 2022,
- ^Numbers, Ronald L., agonize.
(4 November 2015). Newton's Apple and Other Myths about Science. Harvard University Press. doi:10.4159/9780674089167. ISBN .
- ^Ramberg, Peter J. (2000). "The Decease of Vitalism and the Descent of Organic Chemistry: Wohler's Carbamide Synthesis and the Disciplinary Monotony of Organic Chemistry".
Ambix. 47 (3): 170–195. doi:10.1179/amb.2000.47.3.170. PMID 11640223. S2CID 44613876.